RecruitingPhase 2NCT00501826

Combination Chemotherapy and Nelarabine in Treating Patients With T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Phase II Study of Hyper-CVAD Plus Nelarabine in Previously Untreated T-ALL and Lymphoblastic Lymphoma


Sponsor

M.D. Anderson Cancer Center

Enrollment

160 participants

Start Date

Jul 11, 2007

Study Type

INTERVENTIONAL

Conditions

Summary

This phase II trial studies the side effects and how well combination chemotherapy and nelarabine work in treating patients with T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma. Drugs used in chemotherapy, such as cyclophosphamide, vincristine, doxorubicin, dexamethasone, methotrexate, cytarabine, mercaptopurine, prednisone, pegaspargase, nelarabine, and venetoclax work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.


Eligibility

Plain Language Summary

Simplified for easier understanding

This study is testing whether adding a drug called nelarabine to standard chemotherapy improves survival rates in children and young adults with T-cell leukemia or lymphoma (blood cancers that affect a specific type of immune cell). **You may be eligible if...** - You are under 30 years of age and have been newly diagnosed with T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma - Your cancer has been confirmed as T-cell type by laboratory testing - Your general health is adequate to tolerate intensive chemotherapy **You may NOT be eligible if...** - You have already received significant prior chemotherapy for this cancer - You have serious liver, kidney, or heart problems - You are pregnant or breastfeeding - You have a pre-existing nerve condition (peripheral neuropathy) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCyclophosphamide

Given IV

DRUGCytarabine

Given IV

DRUGDexamethasone

Given IV or PO

DRUGDoxorubicin Hydrochloride

Given IV

DRUGMercaptopurine

Given PO

DRUGMethotrexate

Given IV and PO

DRUGNelarabine

Given IV

DRUGPegaspargase

Given IV

DRUGPrednisone

Given PO

DRUGVenetoclax

Given PO

DRUGVincristine Sulfate

Given IV


Locations(1)

M D Anderson Cancer Center

Houston, Texas, United States

View Full Details on ClinicalTrials.gov

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NCT00501826


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