RecruitingNCT00574327

Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry

A Prospective Study To Define The Role Of Various Factors In Development And Progression Of Gastroesophageal Reflux Disease (GERD) And Barrett's Esophagus And The Creation Of A Registry.

Sponsor

Midwest Biomedical Research Foundation

Enrollment

3,000 participants

Start Date

Jan 1, 2006

Study Type

OBSERVATIONAL

Conditions

Esophageal Adenocarcinoma Gastroesophageal Reflux Disease Barrett's Esophagus

Summary

The purpose of this study is to determine or evaluate the risk factors such as smoking, family history etc. that cause esophageal cancer and to determine the genetic changes that lead to esophageal cancer. The investigators hypothesis is that systematic collection of data on the natural history of GERD and BE patients and risk factors for development of BE in patients with chronic GERD and progression of BE to dysplasia and adenocarcinoma will provide useful information to develop a decision model for risk stratification and risk reduction strategies in these patients. As of March 17, 2011, 585 patients have consented at the Kansas City VA Medical Center.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tracks patients with acid reflux (GERD) and Barrett's esophagus (a pre-cancerous change in the food pipe lining) over time to understand who is most likely to progress toward cancer and what factors influence that risk. **You may be eligible if...** - You have been diagnosed with Barrett's esophagus or have chronic severe acid reflux (GERD) - You are willing to undergo regular endoscopy (a camera procedure of the food pipe) as part of the study - You are 18 years of age or older **You may NOT be eligible if...** - You have already been diagnosed with esophageal cancer - You have had surgery on your esophagus or stomach that would affect study results - You are unable or unwilling to undergo follow-up endoscopy procedures Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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