A Natural History Study of the Gangliosidoses

This is a long-term natural history study for patients with gangliosidoses — a group of rare, inherited metabolic disorders (including GM1 and GM2 gangliosidosis, like Tay-Sachs and Sandhoff disease) where harmful substances accumulate in the brain's nerve cells. By tracking how these conditions progress over time, researchers aim to better understand these diseases and prepare for future treatments. You may be eligible if: - You have a documented diagnosis of a gangliosidosis disorder - You are able to participate in neuropsychological and neurobehavioral assessments - If you have late-onset gangliosidosis, you must be able to tolerate a head MRI scan - There is no minimum or maximum age requirement You may NOT be eligible if: - You choose not to participate — there are no other formal exclusion criteria Talk to your doctor to see if this trial is right for you.