RecruitingPhase 2NCT00695214

Drug-Induced Sleep Endoscopy for Upper Airway Evaluation in Obstructive Sleep Apnea


Sponsor

University of California, Los Angeles

Enrollment

800 participants

Start Date

Feb 1, 2004

Study Type

INTERVENTIONAL

Conditions

Summary

Prospective, interventional cohort study of drug-induced sleep endoscopy (DISE) to evaluate the upper airway in a cohort of obstructive sleep apnea (OSA) surgical patients. This study has investigated the reliability of this technique, demonstrating moderate-substantial interrater and test-retest reliability. This research has also compared DISE findings to those of the lateral cephalogram X-ray and examined DISE findings in individuals who have not responded to previous sleep apnea surgery. These papers have been published and available through PubMed. Additional research is ongoing, with examination of DISE findings, comparison to other evaluation techniques, and the association between DISE findings and surgical outcomes.


Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • Adult patients with OSA considering surgical treatment

Exclusion Criteria6

  • Minors
  • Pregnant women
  • Patients unable to provide informed consent in English themselves
  • Prisoners
  • Allergy to propofol, soybean oil, egg lecithin or glycerol
  • Other contraindication to use of propofol (decision of anesthesiologist or otolaryngologist.)

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Interventions

DRUGPropofol sedation

Patients receive an intravenous propofol infusion titrated to reach a target level of sedation, sleep with arousability to verbal stimuli.


Locations(1)

UCLA Santa Monica Medical Center

Santa Monica, California, United States

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NCT00695214


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