RecruitingNCT00777712

Mechanisms Underlying Impaired Diabetic Wound Healing


Sponsor

University of Pittsburgh

Enrollment

250 participants

Start Date

Sep 1, 2008

Study Type

OBSERVATIONAL

Conditions

Summary

The overall aim of this research is to utilize wound derived inflammatory cells from diabetic versus non diabetic human chronic wounds to understand mechanisms that are responsible for disregulated inflammation in individuals with diabetes. Biology of normal (peripheral blood derived cells) versus wound derived cells will also be studied.


Eligibility

Min Age: 21 YearsMax Age: 80 Years

Inclusion Criteria4

  • Ages 21-80
  • Chronic Wound (present \>4 weeks)
  • Diabetic \& Non-diabetic
  • Adult surgical wounds

Exclusion Criteria4

  • Inability to consent
  • Pregnant women
  • Therapeutically immunocompromised
  • Individuals defined in 45 CFR 46 Subparts B,C, and D, nor from any other population considered vulnerable 2.9

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Interventions

OTHERBlood draw

Blood will be drawn from subjects once and VAC sponge will be collected (which is normally discarded material per standard of care).


Locations(5)

Comprehensive Wound Care Centers

Indianapolis, Indiana, United States

Comprehensive Wound Care Centers

Columbus, Ohio, United States

University of Pittsburgh - McKeesport

Pittsburgh, Pennsylvania, United States

University of Pittsburgh - Mercy

Pittsburgh, Pennsylvania, United States

University of Pittsburgh - Passavant

Pittsburgh, Pennsylvania, United States

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NCT00777712


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