RecruitingNot ApplicableNCT00870129

Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors

Using Advanced MR Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans: A Pilot Study, and to Examine Metabolite Changes in Gliomas and Other Solid Tumors


Sponsor

Memorial Sloan Kettering Cancer Center

Enrollment

135 participants

Start Date

Mar 1, 2009

Study Type

INTERVENTIONAL

Conditions

Summary

The researchers think that the use of advanced MR imaging may help people with this disease, because it may better predict areas within a malignant glioma (brain tumor) that are at a high risk of recurring. WeThe reserchers are doing this study to see whether this advanced imaging is a safe treatment that causes few or mild side effects in people with brain tumors.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is using advanced MRI imaging to identify which areas of a brain tumor are most likely to regrow after radiation therapy, so that radiation treatment can be more precisely targeted. **You may be eligible if...** - You are 18 or older - You have a suspected or confirmed high-grade or low-grade brain tumor (glioma), or a tumor suspected to have a specific genetic change (IDH mutation) - You may be planning to undergo radiation therapy - You or your guardian can provide written consent **You may NOT be eligible if...** - You have severe claustrophobia that prevents you from having an MRI - You have a known allergy to gadolinium contrast dye (used in MRI) - You have a pacemaker, aneurysm clip, or other metal implant incompatible with MRI - You are pregnant or nursing - You cannot cooperate for MRI or radiation therapy planning Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREMRI and advanced MRI sequences

This is a nonrandomized study in which each patient will receive the standard clinical care (in the form of surgery, radiation therapy and/or chemotherapy), as per the treating physician. Surgical resection will be performed at the discretion of the treating Neurooncologist and/or Neurooncology Tumor Board. Advanced brain MRIs with the 2 (or, in some cases, 3) special sequences will be obtained at the time of the clinically scheduled contrast MRIs, which are usually obtained immediately prior to and 1 months±3 weeks after radiation therapy if the patient requires radiation therapy for his/her tumor. The advanced brain MRI may also be obtained before surgery for suspected or confirmed gliomas, as per the standard of care, in some patients who may or may not require radiation therapy.


Locations(1)

Memorial Sloan Kettering Cancer Center

New York, New York, United States

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NCT00870129


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