Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers

This study is collecting airway tissue samples during bronchoscopy (a procedure to look inside the airways) to find early biological signals that predict whether pre-cancerous airway changes will progress to lung cancer. **You may be eligible if...** - You have been diagnosed with severe or extensive pre-cancerous changes in your airway lining - You have survived a head and neck or lung cancer for at least 1 year - You are undergoing a bronchoscopy for suspected lung cancer, staging, surveillance, or monitoring - You do not have asthma or active lung disease - You have not had a respiratory illness in the past 2 weeks **You may NOT be eligible if...** - You have a bleeding disorder or are on blood thinners - You have active or unstable heart disease (angina, recent heart attack within 6 weeks, serious heart rhythm problems) - You have serious lung problems preventing safe bronchoscopy - You have had acute bronchitis or pneumonia in the last 8 weeks (unless caused by lung cancer) - Your blood oxygen level is too low (below 90%) even with supplemental oxygen Talk to your doctor to see if this trial is right for you.