Head and Neck Cancer Clinical Trials

243 recruiting

Head and Neck Cancer Trials at a Glance

254 actively recruiting trials for head and neck cancer are listed on ClinicalTrialsFinder across 6 cities in 38 countries. The largest study group is Not Applicable with 88 trials, with the heaviest enrollment activity in New York, Houston, and London. Lead sponsors running head and neck cancer studies include Memorial Sloan Kettering Cancer Center, University of Chicago, and Medical University of South Carolina.

Browse head and neck cancer trials by phase

Treatments under study

About Head and Neck Cancer Clinical Trials

Looking for clinical trials for Head and Neck Cancer? There are currently 243 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Head and Neck Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Head and Neck Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 254 trials

Recruiting

DESTINY-PANTUMOUR04

Liver CancerEsophageal CancerPancreatic Cancer+24 more
AstraZeneca100 enrolled17 locationsNCT07124000
Recruiting
Not Applicable

Velopharyngeal Dysfunction in Head & Neck Cancer Patients, Pilot Study

Head and Neck CancerSurvivorshipDysphagia+2 more
Vanessa Torrecillas20 enrolled1 locationNCT07264036
Recruiting

Nutritional Status of Head and Neck Cancer Patients

Head and Neck CancerRadiotherapyNutritional Status
Marmara University57 enrolled1 locationNCT07068711
Recruiting
Phase 2

ATATcH Alternating Treatment Plans for Advanced Cancer

Lung CancerHead and Neck Cancer
Rutgers, The State University of New Jersey150 enrolled11 locationsNCT05358548
Recruiting
Phase 2

Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population

Head and Neck CancerOropharynx CancerHypopharynx Cancer+3 more
Mayo Clinic25 enrolled1 locationNCT06997068
Recruiting
Not Applicable

The PhOCus Trial: Implementation of Pharmacogenomic Testing in Oncology Care

Breast CancerHead and Neck CancerGastrointestinal Cancer+2 more
University of Chicago860 enrolled1 locationNCT04541381
Recruiting
Not Applicable

Post-Radiation Oral Health in Underserved Head and Neck Cancer Patients

Head and Neck CarcinomaHead and Neck CancerHead and Neck Neoplasms
University of California, San Francisco120 enrolled1 locationNCT07556367
Recruiting
Not Applicable

PromotinG Lung Cancer screenIng Awareness and Implementation in Hispanics/Latinx Head and Neck canceR Survivors

Head and Neck Cancer
University of Miami44 enrolled1 locationNCT06124508
Recruiting
Phase 2

Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)

Head and Neck CancerLaryngeal CancerOral Cavity Cancer+6 more
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins75 enrolled1 locationNCT07209189
Recruiting
Phase 1

A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors

Head and Neck CancerHNSCCColo-rectal Cancer+4 more
ALX Oncology Inc.170 enrolled7 locationsNCT07085091
Recruiting
Phase 2

Invert-Prospective Phase II Randomized Trial of Involved Nodal Versus Elective Neck RadioTherapy

Head and Neck Cancer
University of Texas Southwestern Medical Center80 enrolled1 locationNCT06477692
Recruiting
Phase 2Phase 3

A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1

Unresectable Head and Neck Squamous Cell CarcinomaMetastatic Head and Neck CancerRecurrent Head and Neck Cancer
BioNTech SE350 enrolled193 locationsNCT04534205
Recruiting
Not Applicable

Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Diagnosing Osteoradionecrosis in Patients With Head and Neck Cancer That Is Primary, Has Come Back, or Has Spread to Other Places in the Body

Head and Neck Cancer
M.D. Anderson Cancer Center1,400 enrolled1 locationNCT03145077
Recruiting

New MRI Biomarkers in Head and Neck Cancers

Head and Neck CancerThyroid Cancer
Memorial Sloan Kettering Cancer Center200 enrolled1 locationNCT03483337
Recruiting
Phase 1

Phase I Study of Preconditioning Radiation Therapy With IL-15 Transduced TGFBR2 KO CAR.TROP2-engineered Cord Blood-derived NK Cells in Patients With Advanced Head and Neck Cancer (RADIANCE-NK)

Head and Neck Cancer
M.D. Anderson Cancer Center33 enrolled1 locationNCT07101432
Recruiting
Phase 3

Palliative Steroeotactic Body Radiotherapy vs Palliative Standard Radiotherapy in Patients With Advanced Head and Neck Cancer

Advanced Head and Neck Cancer
Canadian Cancer Trials Group196 enrolled6 locationsNCT06641791
Recruiting
Phase 1Phase 2

Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma

Head and Neck CancerRecurrent Head and Neck Squamous Cell Carcinoma
University of Cincinnati40 enrolled1 locationNCT07213934
Recruiting
Not Applicable

Effect of a Novel Topical Composition on the Incidence of Severe Oral Mucositis in Head & Neck Cancer Radiated Patients and Quality of Life Assessed by PROMs.

PainHead and Neck CancerQuality of Life+6 more
Mucosa Innovations, S.L.63 enrolled1 locationNCT05635929
Recruiting
Phase 2Phase 3

A Trial Evaluating Omission of Radiotherapy to Regional Lymphatic's

Head and Neck Cancer
All India Institute of Medical Sciences396 enrolled1 locationNCT07528495
Recruiting
Phase 2

A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY)

Head and Neck CancerHead and Neck Squamous Cell CarcinomaUnknown Primary Cancer
University of Texas Southwestern Medical Center120 enrolled1 locationNCT05576974