Head and Neck Cancer Clinical Trials

288 recruitingLast updated: June 17, 2026

There are 288 actively recruiting head and neck cancer clinical trials across 39 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1, Phase 4. Top locations include Houston, Texas, United States, New York, New York, United States, Toronto, Ontario, Canada. Updated daily from ClinicalTrials.gov.


Head and Neck Cancer Trials at a Glance

288 actively recruiting trials for head and neck cancer are listed on ClinicalTrialsFinder across 6 cities in 39 countries. The largest study group is Not Applicable with 95 trials, with the heaviest enrollment activity in Houston, New York, and Toronto. Lead sponsors running head and neck cancer studies include Memorial Sloan Kettering Cancer Center, University Health Network, Toronto, and University of Chicago.

Browse head and neck cancer trials by phase

Treatments under study

About Head and Neck Cancer Clinical Trials

Looking for clinical trials for Head and Neck Cancer? There are currently 269 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Head and Neck Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Head and Neck Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 288 trials

Recruiting
Phase 2

Efficacy and Safety Evaluation of VS-101 in Combination With Chemoradiotherapy in Patients With Head and Neck Cancer

Head and Neck Cancer Squamous Cell Carcinoma
VSPharmTech Co.,Ltd.30 enrolled3 locationsNCT06959082
Recruiting
Not Applicable

Locally ablatiVe therApy in oLigO-pRogressive sOlid tUmorS (VALOROUS)

Breast CancerSarcomaHead and Neck Cancer+2 more
University of California, Davis250 enrolled1 locationNCT06103669
Recruiting
Phase 2

PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

Head and Neck CancerHead and Neck Squamous Cell CarcinomaMetastatic Head and Neck Squamous Cell Carcinoma+3 more
Glenn J. Hanna25 enrolled2 locationsNCT06239220
Recruiting
Not Applicable

The SNAP Tool for Head and Neck Cancer Survivor-Caregiver Dyads

Head and Neck CancerSurvivorshipHead and Neck Neoplasms+1 more
Medical University of South Carolina352 enrolled1 locationNCT05811936
Recruiting
Phase 1

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

Triple-Negative Breast CancerPancreatic CancerMelanoma+7 more
Memgen, Inc.40 enrolled2 locationsNCT05076760
Recruiting

Marathon of Hope Cancer Centres Network Study for Ontario (MOHCCN-O)

Breast CancerColorectal, CancerProstate Cancer+9 more
University Health Network, Toronto500 enrolled3 locationsNCT05403177
Recruiting
Phase 1

A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC

Head and NeckHead and Neck Squamous Cell Carcinoma (HNSCC)Head and Neck Cancer+12 more
EpiBiologics110 enrolled6 locationsNCT07462377
Recruiting
Phase 3

Palliative Steroeotactic Body Radiotherapy vs Palliative Standard Radiotherapy in Patients With Advanced Head and Neck Cancer

Advanced Head and Neck Cancer
Canadian Cancer Trials Group196 enrolled8 locationsNCT06641791
Recruiting
Phase 2

Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer

Head and Neck CancerHearing Loss
National Institute on Deafness and Other Communication Disorders (NIDCD)224 enrolled5 locationsNCT04915183
Recruiting
Phase 1Phase 2

Ph. I/II Sodium Thiosulfate for OtoProtection During Cisplatin (STOP-CIS)

Head and Neck CancerThoracic CancerTesticular Cancer+1 more
University of Arizona25 enrolled1 locationNCT07407582
Recruiting

Identification of Predictive Factors for the Response to Anti-Programmed Cell Death Protein 1 (PD1) Immunotherapy in Head and Neck Squamous Cell Carcinoma

Head and Neck Cancer
Centre Paul Strauss60 enrolled1 locationNCT05328024
Recruiting
Phase 2

Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer

Head and Neck CarcinomaHead and Neck CancerOral Cancer+1 more
Case Comprehensive Cancer Center30 enrolled1 locationNCT06627270
Recruiting
Phase 1Phase 2

Lead-212 PSV359 Therapy for Patients With Solid Tumors

Colorectal, CancerEsophageal CancerGastric Cancer+5 more
Perspective Therapeutics112 enrolled8 locationsNCT06710756
Recruiting

A Study of Neurocognitive Tests and Questionnaires for People With Head and Neck Cancer Who Are Undergoing Radiation Therapy

Head and Neck Cancer
Memorial Sloan Kettering Cancer Center60 enrolled7 locationsNCT05207098
Recruiting

Ontario-wide Cancer TArgeted Nucleic Acid Evaluation

Breast CancerColorectal, CancerLung Cancer+8 more
University Health Network, Toronto10,000 enrolled7 locationsNCT02906943
Recruiting
Phase 2

Becotatug Vedotin Combined With Pucotenlimab for Locally Recurrent Resectable Head and Neck Squamous Cell Carcinoma

Head and Neck Cancer
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University102 enrolled1 locationNCT07632339
Recruiting
Not Applicable

Feasibility of Early Swallowing and Speech Intervention for Head and Neck Cancer Patients Treated SURGically

Head and Neck CancerDysphagia
University Health Network, Toronto40 enrolled1 locationNCT06192771
Recruiting

DESTINY-PANTUMOUR04

Liver CancerEsophageal CancerPancreatic Cancer+24 more
AstraZeneca100 enrolled17 locationsNCT07124000
Recruiting
Phase 2Phase 3

Trop2-targeted immunoPET Imaging of Solid Tumors

Liver CancerOvarian CancerCervical Cancer+11 more
RenJi Hospital400 enrolled1 locationNCT06851663
Recruiting

The Role of Dietary Fiber in Mitigating Sarcopenia Risk in Head and Neck Cancer

Head and Neck Cancers
University of Oklahoma59 enrolled1 locationNCT07622914