RecruitingNCT01072825

A European Network for the Investigation of Gender Incongruence


Sponsor

University Hospital, Ghent

Enrollment

125 participants

Start Date

Feb 15, 2010

Study Type

OBSERVATIONAL

Conditions

Summary

The physical and psychological effects of the hormonal treatment of transsexual persons are not sufficiently described. 'Transparency' wants to answer this question in a prospective manner, in a multicenter study to describe these effects. The low prevalence of transsexualism was the stimulus to search for European partners for this Protocol. A common standardized hormonal protocol was designed.


Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • Transsexual persons older then 18 years, who are not yet treated with hormonal therapy.

Exclusion Criteria1

  • \-

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Interventions

OTHERquestionnaires

a descriptive questionnaire, SF-36, , bone questionnaires, Baecke physical activity questionnaire, voice evaluation

BIOLOGICALblood sampling

LFT (AST, ALT), CRP, creatinine, glucose, Total Cholesterol, Triglycerides, HDL-CH, LDL-CH, 25OH vitamin D, PSA if\> 45 years, Hematocrit, testosterone, sex hormone-binding globulin, free testosterone , oestradiol, prolactin, luteinizing hormone, TSH, androgeengevoeligheids test (CAG RL), oral glucose tolerance test

OTHERclinical evaluation

height, weight, blood pressure, chestcircumference, waist circumference, grip strength, measuring 2 ° and 4 ° finger, and Ferriman Gallwey score

OTHERDermatology evaluation

Evaluation of the hair pattern, using the Leeds acne classification scale, acne scars through ECCA scale (échelle d'évaluation clinique des cicatrices d'acné), androgenetic alopecia, and sebummetrie

OTHERBone evaluation

PQCT scanner, BMD assessment


Locations(4)

Genderteam UZ Gent

Ghent, Belgium

Florence, Italy

VU University Medical CenterAmsterdam

Amsterdam, Netherlands

Rikshospitalet University Hospital, University of Oslo

Oslo, Norway

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NCT01072825