RecruitingNCT01241305

One-Time DNA Study for Vasculitis

VCRC Genetic Repository One-Time DNA Protocol

Sponsor

University of Pennsylvania

Enrollment

1,000 participants

Start Date

Oct 1, 2010

Study Type

OBSERVATIONAL

Conditions

Microscopic Polyangiitis Giant Cell Arteritis Takayasu's Arteritis Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)Granulomatosis With Polyangiitis (Wegener's)Polyarteritis Nodosa

Summary

The purpose of this study is to identify genes that increase the risk of developing vasculitis, a group of severe diseases that feature inflammation of blood vessels. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.

Eligibility

Min Age: 7 Years

Plain Language Summary

Simplified for easier understanding

This one-time study collects a DNA (blood) sample from people with certain types of vasculitis — diseases that cause inflammation of blood vessels. These include Giant Cell Arteritis, Takayasu's Arteritis, Polyarteritis Nodosa, Granulomatosis with Polyangiitis (Wegener's), Microscopic Polyangiitis, and Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss). The genetic data collected will help researchers understand why these diseases develop and vary between individuals. You may be eligible if... - You have a confirmed diagnosis of one of the vasculitis types listed above, based on established diagnostic criteria - You are 7 years of age or older - You are willing to provide a blood sample for DNA collection You may NOT be eligible if... - You are unable to give informed consent - You are already enrolled in related VCRC study protocols (5502–5506, 5522, or 5523) - You are unwilling to provide a blood sample Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(14)

Cedars-Sinai Medical Center

Los Angeles, California, United States

University of California, San Francisco

San Francisco, California, United States

Northwestern University

Chicago, Illinois, United States

University of Kansas Medical Center

Kansas City, Kansas, United States

University of Michigan

Ann Arbor, Michigan, United States

Mayo Clinic

Rochester, Minnesota, United States

Hospital for Special Surgery

New York, New York, United States

Cleveland Clinic

Cleveland, Ohio, United States

University of Pennsylvania

Philadelphia, Pennsylvania, United States

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

University of Utah

Salt Lake City, Utah, United States

St. Joseph's Healthcare

Hamilton, Ontario, Canada

Mount Sinai Hospital

Toronto, Ontario, Canada

Istanbul University

Istanbul, Fatih, Turkey (Türkiye)

View Full Details on ClinicalTrials.gov

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NCT01241305

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