Wide-Field and High Resolution In Vivo Imaging in Visualizing Lesions in Patients With Oral Neoplasia Undergoing Surgery

This study uses two advanced imaging tools — wide-field and high-resolution microscopic imaging — during surgery to help doctors see the full extent of mouth (oral) cancers and get a clearer picture of tumor edges in real time. **You may be eligible if...** - You are an adult with a mouth (oral) lesion or tumor who is scheduled for surgery or biopsy of the head and neck area - Prior treatment for oral cancer is allowed - You are willing and able to sign a consent form **You may NOT be eligible if...** - You have a known allergy to proflavine or acriflavine (dyes used during imaging) - You are pregnant or breastfeeding - You are actively receiving an experimental drug or treatment on another clinical trial Talk to your doctor to see if this trial is right for you.