Natural History Study - Mitochondrial Disease

This natural history study follows people who carry the m.3243 A>G mitochondrial DNA mutation — a genetic change that can cause a range of conditions including MELAS syndrome, hearing loss, and diabetes. Researchers also enroll family members to understand how the mutation is inherited and how it affects health across generations. You may be eligible if: - You are 4 years of age or older - You are a known carrier of the m.3243 A>G mitochondrial mutation - OR you are maternally related to someone who carries this mutation - OR you are a non-maternally-related family member You may NOT be eligible if: - You are under 4 years of age - There is no confirmed m.3243 A>G mutation in your family Talk to your doctor to see if this trial is right for you.