Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate

This study is investigating the genetic causes of reproductive and hormonal disorders — including conditions where puberty does not develop normally, irregular menstrual cycles, polycystic ovaries, and cleft lip or palate — to better understand how genes influence these conditions. **You may be eligible if...** - You have one of the following conditions: hypogonadotropic hypogonadism (the body does not produce enough sex hormones), Kallmann syndrome (a condition combining lack of puberty with a reduced sense of smell), hypothalamic amenorrhea (missed periods due to a hormonal imbalance), polycystic ovarian syndrome (PCOS), premature ovarian failure, early puberty, or cleft lip or palate - You are a family member of someone with one of the above conditions **You may NOT be eligible if...** - You are currently acutely ill or hospitalized - You have a pituitary tumor, iron overload (hemochromatosis), sarcoidosis, chronic alcohol abuse, or illicit drug use - You have other medical conditions that could explain your hormone or reproductive symptoms Talk to your doctor to see if this trial is right for you.