RecruitingPhase 1NCT01731444

Phenylephrine Tumescence for Hemostasis in Surgery for Burn Injury

Phenylephrine Tumescence for Hemostasis in Surgery for Burn Injury - A Randomized Control Trial

Sponsor

University of Manitoba

Enrollment

24 participants

Start Date

Dec 1, 2014

Study Type

INTERVENTIONAL

Conditions

Blood Loss, Surgical

Summary

The standard of care for treatment of burn injury is to inject a solution of epinephrine under the skin of the injured site in order to reduce blood loss during skin grafting. This solution of epinephrine has been shown to have effects on the body outside the donor site. Some people have increases in heart rate and blood pressure. We will study the effect of a phenylephrine solution in place of an epinephrine solution to control blood loss. We think that phenylephrine will help decrease blood loss and not change blood pressure or heart rate. The injured area will be injected under the skin and a skin graft will be taken in the same way as we usually do. The only change will be the use of phenylephrine in the solution instead of epinephrine. Our goal is to find whether or not phenylephrine or epinephrine solution results in a reduction of blood loss without affecting the rest of the body.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether injecting a diluted solution of phenylephrine (a blood vessel constrictor) into the tissue under burn wounds reduces bleeding during burn wound surgery, potentially improving outcomes for patients needing skin grafting. You may be eligible if: - You are 18 to 75 years of age - You have a burn injury covering 5–30% of your total body surface area that requires surgical debridement and skin grafting You may NOT be eligible if: - Your burns involve the head and neck, hands, feet, or genitals - You are on anticoagulants (blood thinners), excluding NSAIDs - You take monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants - You have coronary artery disease or peripheral vascular disease - You have a history of heart rhythm problems (arrhythmias) - You are on a beta-blocker medication - You have a history of vascular abnormalities - You have hypertension (high blood pressure) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.