RecruitingNCT01851395

Rapid Autopsy and Procurement of Cancer Tissue

Inpatient Hospice With Procurement of Tissue on Expiration in Thoracic Malignancies, Bladder Cancer, Ovarian Cancer, Epithelial Cancer and Patients Treated With an Adoptive Cellular Therapy


Sponsor

National Cancer Institute (NCI)

Enrollment

275 participants

Start Date

Dec 30, 2013

Study Type

OBSERVATIONAL

Conditions

Summary

Background: \- Individuals with cancer of the lung, chest cavity, ovary, or bladder, as well as patients who have been treated with adoptive cell therapy unfortunately commonly succumb to their disease. Some agree to donate their bodies to cancer research that may help the medical community better understand these diseases. Studies of cancer tumor tissue obtained soon after death may be used to answer questions about the origins, progression, and treatment of cancer. Researchers want to conduct a study that involves planned collection of cancer tumor tissue shortly after death. To do so, they will arrange to provide inpatient hospice care for people with lung cancer, ovarian cancer, bladder cancer, or patients who have been treated with adoptive cell therapy. \<TAB\> Objectives: \- To collect cancer tissue biopsy samples as soon as possible after death. Eligibility: \- Individuals who have cancer of the lung, chest cavity, ovary, or bladder, or those who have been treated with adoptive cell therapy and are planning to receive end-of-life hospice care are eligible to participate. Design: * Participants will agree to receive inpatient hospice care at the National Institutes of Health Clinical Center. Full details on end-of-life care preference will be acknowledged. * An autopsy will be performed at the clinical center within 3 hours of death. Tumor tissue will be collected from the primary site of cancer and from any areas of the body to which the cancer has spread. * Participants will not receive further cancer treatments as part of this study. This is a tissue collection study only.


Eligibility

Min Age: 18 YearsMax Age: 120 Years

Plain Language Summary

Simplified for easier understanding

This study is a rapid autopsy program that collects tissue from people with certain advanced cancers shortly after death, to help researchers study how cancer grows, spreads, and resists treatment at its most advanced stage. **You may be eligible if...** - You have been confirmed to have advanced, incurable lung cancer (NSCLC or SCLC), mesothelioma, certain rare lung or thymic cancers, bladder cancer, ovarian cancer, or several other epithelial cancers (breast, colon, pancreatic, stomach, biliary) - You are 18 or older and understand this is a research study - You are willing to designate a durable power of attorney and agree to a Do Not Resuscitate (DNR) order as part of end-of-life planning **You may NOT be eligible if...** - You are known to be pregnant - You are known to be HIV positive (due to risk of tissue contamination) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

National Institutes of Health Clinical Center

Bethesda, Maryland, United States

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NCT01851395


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