Modified Vaccine for High Risk or Low Residual Melanoma Patients

This study is testing a modified vaccine approach to help the immune system recognize and fight melanoma (a type of skin cancer) in patients who are at high risk of the cancer coming back or who have a small amount of remaining disease after treatment. **You may be eligible if...** - You have been diagnosed with melanoma that is considered high risk or you have a small amount of remaining disease - You have completed primary treatment and your doctor thinks a vaccine approach may help - You are in generally good health and able to attend regular study visits - You meet specific blood and organ function requirements **You may NOT be eligible if...** - You have active, spreading melanoma throughout your body - You have a weakened immune system or are taking medications that suppress immunity (such as steroids) - You have serious autoimmune conditions (where the immune system attacks the body) - You are pregnant or breastfeeding - You have had prior treatments that would interfere with the vaccine's effectiveness Talk to your doctor to see if this trial is right for you.