RecruitingNCT02038166

Nasal Potential Difference (NPD) Protocol in Chronic Rhinosinusitis

Chloride Secretagogues for Acquired CFTR Dysfunction in Chronic Rhinosinusitis (NPD Protocol)

Sponsor

University of Alabama at Birmingham

Enrollment

20 participants

Start Date

Jan 1, 2015

Study Type

OBSERVATIONAL

Conditions

Rhinosinusitis

Summary

The purpose of this study is to determine if acquired (partial) Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) deficiency contributes substantially to the pathogenic mechanisms underlying Chronic Rhinosinusitis (CRS), creating a localized environment that impairs mucociliary clearance (MCC).

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether a protein channel called CFTR — best known for its role in cystic fibrosis — also becomes partially dysfunctional in the nasal passages of people with chronic rhinosinusitis (CRS), a long-term sinus inflammation condition, and whether this contributes to the mucus clearance problems seen in CRS. Researchers use a specialized test called nasal potential difference (NPD) measurement, which uses small amounts of fluid dripped into the nose to measure how well the nasal lining transports ions. Adults aged 19 and older with a confirmed CRS diagnosis and a weight of at least 50 kg can participate, though those with a recent acute illness, significant asthma attack in the past 2 months, or organ transplant history are not eligible. Participation involves the NPD nasal test during or around a scheduled endoscopic sinus procedure, along with blood and urine tests. This summary was prepared with AI assistance to help patients understand the study in plain language.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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