Complex Aortic Aneurysm Repair Using Physician Modified Endografts and Custom Made Devices

This study is evaluating the safety and effectiveness of customized or physician-modified endovascular grafts for repairing complex aortic aneurysms — dangerous enlargements of the main artery — in patients whose anatomy makes standard commercial devices unsuitable or who cannot safely wait for a custom device to be manufactured. The repairs are performed through small groin incisions using stent grafts with additional openings to maintain blood flow to vital organs like the kidneys and intestines. Adults aged 18 and older with aortic aneurysms of 5.5 cm or larger, or rapidly growing smaller aneurysms, who are at high risk for open surgery may be eligible. Participation involves undergoing the endovascular repair procedure and follow-up imaging and clinic visits for up to five years. This summary was prepared to help patients understand the study in plain language.