RecruitingNCT02061306

Celiac Disease Genomic Environmental Microbiome and Metabolomic Study

Celiac Disease Genomic Environmental Microbiome and Metabolomic (CDGEMM) Study


Sponsor

Massachusetts General Hospital

Enrollment

500 participants

Start Date

Mar 1, 2014

Study Type

OBSERVATIONAL

Conditions

Summary

Celiac disease (CD) is a complex disease caused by eating gluten, a protein contained in wheat, rye, and barley. It is well known that many factors contribute to the development of CD, including the genes that you have and the foods that you eat. In the CDGEMM study, we will consider as many of these factors as possible and study how they each contribute to disease development. If the investigators find that any one factor, or combination of factors, increases the risk of developing CD, we will be able to apply this information and help prevent or detect disease in high-risk children in the future.


Eligibility

Max Age: 6 Months

Inclusion Criteria2

  • Newborns and infants less than 6 months of age who have not been introduced to solid foods (exclusive breast milk or formula diet)
  • First-degree relatives of patients affected with biopsy-proven CD

Exclusion Criteria2

  • Infants older than 6 months of age
  • Inability or unwillingness of legal guardian/representative to give written informed consent

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Locations(2)

MassGeneral Hospital for Children

Boston, Massachusetts, United States

University of Roma La Sapienza

Rome, Italy

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NCT02061306


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