RecruitingNCT02073500

Peritoneal Surface Malignancies - Characterization, Models and Treatment Strategies

Prospective Observational Study of Peritoneal Surface Malignancies (PSM) - Characterization, Models and Treatment Strategies.

Sponsor

Oslo University Hospital

Enrollment

300 participants

Start Date

Sep 1, 2009

Study Type

OBSERVATIONAL

Conditions

Ovarian Carcinoma Colorectal Carcinoma Mesothelioma Pseudomyxoma Peritonei

Summary

The aim of this study is to identify biomarkers of disease recurrence and prognosis to optimize patient selection for treatment with cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC), and through animal models to explore different treatment strategies for peritoneal surface malignancies (PSM).

Eligibility

Min Age: 18 Years

Inclusion Criteria4

age \> 18 years
confirmed diagnosis of peritoneal surface malignancy
candidate for CRS-HIPEC
written informed consent

Exclusion Criteria2

none
Approximately 80 patients per year will be eligible for inclusion, as this is the number of patients that annually receive surgical treatment for PSM.

Interventions

OTHERObservational study.

Analysis of metastatic tissue and blood specimens collected from patients with PSM undergoing CRS-HIPEC. CRS: Removal of all macroscopically detectable tumor. HIPEC: Instillation of heated chemotherapy in the abdominal cavity to remove residual cancer disease.