Exploring Vancomycin Disposition in Neonates
Exploring Vancomycin Disposition in Neonates: Paired Analysis of Vancomycin Concentrations Using Immunoassay and Liquid-chromatography-tandem Mass Spectrometry. Determination of Vancomycin Protein Binding and Its Covariates in Neonates
Universitaire Ziekenhuizen KU Leuven
120 participants
Apr 1, 2014
INTERVENTIONAL
Conditions
Summary
Vancomycin is already used for decades in neonates. However, there are remaining questions concerning vancomycin disposition in this population. The purpose of this study is first of all to perform a paired analysis of serum vancomycin concentrations using an immunoassay versus a reference liquid chromatography-tandem mass spectrometry method. Secondly, we aim to determine vancomycin protein binding and its covariates in neonates.
Eligibility
Inclusion Criteria1
- Neonates, admitted to the Neonatal Intensive Care Unit to whom vancomycin is administered for medical reasons, can be included in the study after informed consent of the parents.
Exclusion Criteria2
- No vancomycin therapy
- No signed informed consent available
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
vancomycin administration based on decision of treating physician
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT02096536