Exploring Vancomycin Disposition in Neonates
Exploring Vancomycin Disposition in Neonates: Paired Analysis of Vancomycin Concentrations Using Immunoassay and Liquid-chromatography-tandem Mass Spectrometry. Determination of Vancomycin Protein Binding and Its Covariates in Neonates
Universitaire Ziekenhuizen KU Leuven
120 participants
Apr 1, 2014
INTERVENTIONAL
Conditions
Summary
Vancomycin is already used for decades in neonates. However, there are remaining questions concerning vancomycin disposition in this population. The purpose of this study is first of all to perform a paired analysis of serum vancomycin concentrations using an immunoassay versus a reference liquid chromatography-tandem mass spectrometry method. Secondly, we aim to determine vancomycin protein binding and its covariates in neonates.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
vancomycin administration based on decision of treating physician
Locations(1)
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NCT02096536