A Study of Systemic Chemotherapy With/Without HAI in Patients With Initially Unresectable Colorectal Liver Metastasis

This trial is studying whether adding a specialized treatment directly to the liver's blood supply (called Hepatic Arterial Infusion, or HAI) — in addition to standard chemotherapy given through the bloodstream — can help shrink liver tumors caused by colorectal cancer that have spread to the liver and cannot currently be removed with surgery. **You may be eligible if...** - You are 18 to 70 years old - You have colorectal cancer that has spread to the liver only (no spread to other organs) - A team of doctors has confirmed the liver tumors cannot currently be surgically removed - You have not previously received any treatment for the liver metastases - Your blood counts, liver, and kidney function are at acceptable levels **You may NOT be eligible if...** - The cancer has spread outside the liver - You have severe circulation problems, fluid build-up in the abdomen (ascites), or clotting disorders - You have uncontrolled high blood pressure or serious heart, lung, kidney, or gastrointestinal problems - You are pregnant Talk to your doctor to see if this trial is right for you.