Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin

This study investigates whether oral vancomycin (an antibiotic) can treat primary sclerosing cholangitis (PSC) and biliary atresia — serious liver and bile duct diseases. Researchers also study gut bacteria (microbiome) samples from patients undergoing endoscopy and those with related bowel conditions to understand the role of bacteria in these diseases. You may be eligible if: - You have primary sclerosing cholangitis (PSC), biliary atresia, or a chronic intestinal disorder - You are undergoing upper or lower endoscopy - You are between 2 weeks and 40 years old - You are considered a good candidate for vancomycin therapy (if receiving treatment) You may NOT be eligible if: - You have taken antibiotics or immunomodulators within the last 3 months (as this alters gut bacteria) - You are pregnant Talk to your doctor to see if this trial is right for you.