RecruitingNCT02146170

Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors

Tissue Procurement and Natural History Study of Patients With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors


Sponsor

National Cancer Institute (NCI)

Enrollment

2,000 participants

Start Date

May 28, 2014

Study Type

OBSERVATIONAL

Conditions

Summary

Background: \- Lung cancer is the leading cause of cancer-related death worldwide. It causes more than one million deaths every year. Researchers want to gather tissue samples from people with lung and thymic cancers to understand the disease better. This may lead to new ways to diagnose and treat it. Objective: \- To collect tissue samples for use in the study of lung cancers. Eligibility: \- Adults over age 18 with non-small cell lung cancer, small cell lung cancer, extra pulmonary small cell cancer, pulmonary neuroendocrine tumors, and thymic epithelial tumors. Design: * Participants will be screened with a medical history, physical exam, and blood tests. They will be asked about how they perform their daily tasks. * Participants may be asked to give urine and blood samples. They may give a saliva sample if they cannot give blood. They will also give a sample of their tumor from a biopsy they had. They may also be given the option to undergo a biopsy. * Participants may have MRI, CT, and/or PET scans of the body. They will lie in a machine that takes pictures of the body. * After visits to the Clinical Center end, researchers will contact participants by phone every year to check on their health.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is a tissue collection and natural history study — not a treatment trial — that gathers tumor tissue and blood samples from people with thoracic (chest-area) cancers, including non-small cell lung cancer, small cell lung cancer, esophageal squamous cell cancer, pancreatic neuroendocrine tumors, and thymic tumors. The goal is to support research into understanding how these cancers develop, grow, and respond to treatment over time. **You may be eligible if...** - You are 18 or older - You have a confirmed or clinically suspected thoracic cancer (such as lung cancer, esophageal cancer, or a related chest tumor) - You are able to understand and sign a written informed consent form **You may NOT be eligible if...** - You have a serious unstable medical condition — such as a recent heart attack or severe heart failure — that would make a biopsy procedure unsafe - You are HIV-positive and not on effective antiretroviral treatment - You are under 18 years of age Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

National Institutes of Health Clinical Center

Bethesda, Maryland, United States

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NCT02146170


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