RecruitingNCT02164409

Changes Associated With H. Pylori and Gastric Carcinogenesis

Next-Generation Sequencing to Evaluate Transcriptomic Changes Associated With H. Pylori Infection and Gastric Cancer Carcinogenesis

Sponsor

Weill Medical College of Cornell University

Enrollment

120 participants

Start Date

Jul 1, 2012

Study Type

OBSERVATIONAL

Conditions

Bacterial Infection Due to Helicobacter Pylori (H. Pylori)

Summary

This is a research study for patients who currently have or previously had an H. pylori infection or who have gastric or esophageal cancer and who plan to undergo an endoscopy as part of their care. The purpose of this study is to find out how and why H. pylori infections can cause progression to gastric cancer and if it's possible for intervention prior to this progression.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how infection with H. pylori — a common stomach bacteria linked to ulcers and stomach cancer — leads to changes in the stomach lining over time that can eventually develop into stomach or esophageal cancer, including a pre-cancerous condition called Barrett's esophagus. **You may be eligible if...** - You are 18 or older - You have had, currently have, or have been treated for H. pylori infection — OR you have been diagnosed with stomach cancer, esophageal cancer, or Barrett's esophagus - You are already scheduled for a routine upper endoscopy (a camera procedure to look at the stomach) - You are able to sign informed consent **You may NOT be eligible if...** - You have had a major upper GI bleed within the past 3 months - You have a blood clotting disorder - You have had a stroke or heart attack within the past 3 months Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREEndoscopy tissue collection

The investigational part of this study is the requirement for an additional biopsy from a site that is already being biopsied at the time of a routine endoscopy. Any patients who develop bleeding following their routine clinical biopsies will not undergo any additional research biopsies.

Locations(1)

Weill Cornell Medical College

New York, New York, United States

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NCT02164409