Changes Associated With H. Pylori and Gastric Carcinogenesis
Next-Generation Sequencing to Evaluate Transcriptomic Changes Associated With H. Pylori Infection and Gastric Cancer Carcinogenesis
Weill Medical College of Cornell University
120 participants
Jul 1, 2012
OBSERVATIONAL
Conditions
Summary
This is a research study for patients who currently have or previously had an H. pylori infection or who have gastric or esophageal cancer and who plan to undergo an endoscopy as part of their care. The purpose of this study is to find out how and why H. pylori infections can cause progression to gastric cancer and if it's possible for intervention prior to this progression.
Eligibility
Inclusion Criteria4
- Patient must be 18 years or older
- Patient must have active or prior H. pylori infection, or have been treated for H.pylori infection in the past, as assessed by ELISA (not applicable for the subset of patient controls) or have gastric or esophageal cancer or have Barrett's Esophagus
- Patients must be eligible for and are planning to undergo a routine upper endoscopy and tissue biopsy
- Patients must sign informed consent
Exclusion Criteria3
- Prior history of upper GI bleed (within 3 months)
- Bleeding disorder or coagulopathy
- Recent stroke or myocardial infarction (within 3 months)
Interventions
The investigational part of this study is the requirement for an additional biopsy from a site that is already being biopsied at the time of a routine endoscopy. Any patients who develop bleeding following their routine clinical biopsies will not undergo any additional research biopsies.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT02164409