Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer

This trial is testing a drug called tirapazamine combined with a procedure called embolization (blocking the blood supply to liver tumors) in people with neuroendocrine tumors (NETs) that have spread to the liver, to see if cutting off oxygen to the tumor while delivering this drug enhances its ability to kill cancer cells. **You may be eligible if...** - You are 20 or older with neuroendocrine tumors (slow-growing tumors) that have spread primarily to the liver - Your liver tumors have been growing despite previous treatment - The liver tumors make up less than 50% of your total liver volume - You are well enough to carry out normal activities (ECOG 0–1) - Your heart, lungs, kidneys, and blood function are at acceptable levels - You are eligible for the embolization procedure **You may NOT be eligible if...** - The main blood vessel to your liver (portal vein) is blocked - You have significant heart, lung, or kidney problems - You are pregnant or are a male partner of a woman who could become pregnant and are unwilling to use contraception Talk to your doctor to see if this trial is right for you.