RecruitingNot ApplicableNCT02222844

Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers


Sponsor

Imperial College London

Enrollment

244 participants

Start Date

Aug 1, 2014

Study Type

INTERVENTIONAL

Conditions

Summary

Patients with suspected or proven sigmoid colon adenocarcinoma, eligible for curative treatment whose MRI can be reviewed prior to surgery and has no decision regarding radical treatment are eligible. Patient are randomised to the control arm which the standard care of preoperative CT imaging and subsequent discussion by the Multidisciplinary Team or the interventional arm which has the additional use of MRI imaging and subsequent discussion by the Multidisciplinary Team. Patients are followed up at 1 and 3 years together with QoL questionnaires.


Eligibility

Min Age: 16 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating whether using detailed MRI scans to assess sigmoid colon cancer (a cancer in the lower part of the large intestine) before surgery can improve surgical planning and help doctors decide whether patients should receive chemotherapy or radiation before their operation. **You may be eligible if...** - You are 16 or older - You have a suspected or confirmed sigmoid colon cancer - You are eligible for surgery intended to cure the cancer - The cancer has not spread to other parts of the body (no metastatic disease) - You have not yet had a final treatment decision made - You have signed an informed consent form **You may NOT be eligible if...** - Your cancer has spread to other organs (including resectable liver metastases) - You have a second cancer at the same time - You cannot have an MRI scan (e.g., due to a pacemaker or metal implants) - You have an allergy to Buscopan (an antispasmodic medication used during the MRI) - You have severe health problems that prevent chemotherapy or radiation if needed Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERPreoperative MRI scan

Standard preoperative CT of abdomen, chest and pelvis plus interventional preoperative MRI scan.


Locations(16)

Hinchingbrooke Hospital

Huntingdon, Cambridgeshire, United Kingdom

Leighton Hospital

Crewe, Cheshire, United Kingdom

University Hospital of North Tees

Stockton-on-Tees, County Durham, United Kingdom

Croydon University Hospital

Thornton Heath, Croydon, United Kingdom

Chesterfield Royal

Chesterfield, Derbyshire, United Kingdom

Queen Alexandra Hospital

Portsmouth, Hampshire, United Kingdom

St Mark's Hospital

Middlesex, Harrow, United Kingdom

Maidstone Hospital

Maidstone, Kent, United Kingdom

Queen Elizabeth the Queen Mother Hospital

Margate, Kent, United Kingdom

North Manchester General Hospital

Crumpsall, Manchester, United Kingdom

University Hospital of South Manchester & Manchester Royal Infirmary

Wythenshawe, Manchester, United Kingdom

Harrogate District Hospital

Harrogate, North Yorkshire, United Kingdom

Musgrove Park Hospital

Taunton, Somerset, United Kingdom

Yeovil District Hospital

Yeovil, Somerset, United Kingdom

Royal Marsden Hospital

Sutton, Surrey, United Kingdom

Salisbury District Hospital

Salisbury, Whiltshire, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT02222844


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