RecruitingNot ApplicableNCT02246634

Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI (SERENADE)

Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI.


Sponsor

Imperial College London

Enrollment

282 participants

Start Date

Aug 1, 2014

Study Type

INTERVENTIONAL

Conditions

Summary

Eligible patients with high risk colorectal malignancy (T3/4, spread greater than 5mm, EMVI positive) will have additional surveillance of breath hold T1, T2 and DW-MRIs (no IV contrast) post surgery six monthly for three years. Findings of liver MRIs as reported by radiology PI will be shared with their local MDT who make decisions as appropriate, including the management of any identified liver metastases, according to local protocol.


Eligibility

Min Age: 16 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying whether a special type of MRI scan (called DW-MRI, which detects how water moves through tissue) can find cancer spread to the liver in people with colorectal cancer more accurately than a standard CT scan. **You may be eligible if...** - You have been diagnosed with high-risk colorectal cancer (cancer of the colon or rectum) - Your CT scan has not confirmed cancer spread to the liver - You are able to receive treatment if liver cancer spread is found - You are 16 years of age or older **You may NOT be eligible if...** - You had a previous colorectal cancer - Your cancer has already spread to other parts of the body - You have a second cancer at the same time - You cannot have an MRI scan (for example, if you have a pacemaker) - Your rectal tumor is classified as T3b or lower Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERDiffusion Weighted MRI scan

Liver metastases found on the additional DW-MRI scans will be discussed at MDT and treated according to local site policy.


Locations(13)

Macclesfield District General Hospital

Macclesfield, Cheshire, United Kingdom

Queen's Hospital

Burton-on-Trent, Derbyshire, United Kingdom

Broomfield Hospital

Chelmsford, Essex, United Kingdom

Royal Bolton Hospital

Bolton, Greater Manchester, United Kingdom

Medway Maritime Hospital

Gillingham, Kent, United Kingdom

University Hospital of South Manchester & Manchester Royal Infirmary

Wythenshawe, Manchester, United Kingdom

Royal Liverpool Hospital

Liverpool, Merseyside, United Kingdom

Royal Stoke University Hospital

Stoke-on-Trent, Staffordshire, United Kingdom

Royal Marsden Hospital

Sutton, Surrey, United Kingdom

Royal Gwent Hospital

Newport, Wales, United Kingdom

George Eliot Hospital

Nuneaton, Warwickshire, United Kingdom

Salisbury District Hospital

Salisbury, Wiltshire, United Kingdom

Queen Alexandra Hospital

Portsmouth, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT02246634


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