Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI (SERENADE)
Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI.
Imperial College London
282 participants
Aug 1, 2014
INTERVENTIONAL
Conditions
Summary
Eligible patients with high risk colorectal malignancy (T3/4, spread greater than 5mm, EMVI positive) will have additional surveillance of breath hold T1, T2 and DW-MRIs (no IV contrast) post surgery six monthly for three years. Findings of liver MRIs as reported by radiology PI will be shared with their local MDT who make decisions as appropriate, including the management of any identified liver metastases, according to local protocol.
Eligibility
Inclusion Criteria5
- Have a high risk primary colorectal malignancy
- Have a negative CT or includes no confirmatory evidence of liver metastases
- Is able to undergo treatment if liver metastasis is found
- Have provided written informed consent to participate in the study
- Be aged 16 years or over
Exclusion Criteria5
- Have had a previous colorectal malignancy
- Have metastatic disease
- Have a synchronous second malignancy
- Are contraindicated for MRI
- Has a T3b or below low rectal tumour without EMVI or N1c
Interventions
Liver metastases found on the additional DW-MRI scans will be discussed at MDT and treated according to local site policy.
Locations(13)
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NCT02246634