Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults
Use of Hyperpolarized 129 Xe MR Lung Imaging in Children and Adults
Children's Hospital Medical Center, Cincinnati
300 participants
Dec 1, 2014
INTERVENTIONAL
Summary
The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults and also in children with respiratory compromise due to a variety of diseases.
Eligibility
Inclusion Criteria2
- Ages 6 and up
- Participant must be able to hold breath for up to 16 seconds
Exclusion Criteria7
- History of heart defect
- Pregnancy or positive pregnancy test
- History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month
- Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week
- Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula
- Participant is claustrophobic and unable to tolerate the imaging.
- Standard MRI exclusions (metal, implants)
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Interventions
During the scans, subject will inhale hyperpolarized Xenon gas for up to 16 seconds per scan, for up to 4 separate MR scans
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT02272049