RecruitingNot ApplicableNCT02292641

Beyond TME Origins

Investigating the Origins of Pelvic Recurrence in Colorectal Cancer

Sponsor

Imperial College London

Enrollment

383 participants

Start Date

Sep 25, 2014

Study Type

INTERVENTIONAL

Conditions

Carcinoma Neoplasms Adenocarcinoma

Summary

All patients with recurrent colorectal cancer in the pelvis are eligible. The original primary tumour staging scans and resected surgical specimen needs to be available. Patients' recurrence will be staged using our proposed MRI classification. We will be assessing the original primary staging scans and histopathology to learn about risk factors for recurrence. We will record treatment for the recurrence, and patients will be followed up for three years.

Eligibility

Min Age: 16 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying the origins of colorectal cancer that comes back in the pelvis after initial surgery (called recurrent pelvic colorectal cancer) to understand how and why it returns, with the goal of improving treatments. **You may be eligible if...** - You have been confirmed by biopsy to have had primary colorectal cancer (cancer of the colon or rectum) - Your colorectal cancer has been confirmed to have returned in the pelvis - You previously had surgery to treat the original cancer - You are able to have a high-resolution MRI scan - You are 16 years of age or older **You may NOT be eligible if...** - You have not had previous surgery for colorectal cancer - You are unable to have an MRI scan - You have not given written consent to participate Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURENew Radiological Staging Classification system for patients with advanced and recurrent colorectal cancer undergoing pelvic exenterative surgery

Currently there are no validated criteria or guidelines for judging whether advanced primary or recurrent colorectal cancer can be successfully removed and for selecting which patients should undergo this form of more radical surgery as is exenterative surgery. We are proposing that by validating the detailed evaluation of imaging of the tumour distribution within the pelvis using a new radiological staging classification, this will enable clear selection criteria to be established and will improve surgical planning.