Direct or Subacute Coronary Angiography in Out-of-hospital Cardiac Arrest
Direct or Subacute Coronary Angiography in Out-of-hospital Cardiac Arrest - a Prospective, Randomized Study
Uppsala University
1,006 participants
Dec 1, 2014
INTERVENTIONAL
Summary
The overall aim of this prospective, randomized study is to investigate whether acute coronary angiography (within 120 minutes) with a predefined strategy for revascularization, will improve 30-day survival in patients with out of hospital cardiac arrest with no signs of ST-elevation on ECG after Restoration of Spontaneous Circulation (ROSC). The patients will be randomized to a strategy of immediate coronary angiography within 120 minutes or to a strategy of delayed angiography that may be performed three days after the cardiac arrest.
Eligibility
Inclusion Criteria3
- Witnessed out of hospital cardiac arrest
- Restoration of Spontaneous Circulation (ROSC) >20 minutes
- Coronary angiography is expected to be performed within 120 minutes from inclusion and randomization at hospital
Exclusion Criteria6
- Patient age <18 years
- Obvious extracardiac genesis of cardiac arrest such as trauma, hemorrhagic shock, and / or asphyxia (eg drowning, suffocation, hanging, exposure to fire smoke)
- Terminally ill patients with a life expectancy of less than 1 year
- Patients with ST-elevation
- Known pregnancy
- Patient awake GCS >8 (Glasgow Coma Scale)
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Interventions
Immediate coronary angiography for out of hospital cardiac arrest patients with no signs of ST elevation on their first ECG after ROSC
Locations(21)
View Full Details on ClinicalTrials.gov
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NCT02309151