RecruitingPhase 1Phase 2NCT02316379
Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration
Sponsor
Children's Hospital Medical Center, Cincinnati
Enrollment
100 participants
Start Date
Feb 1, 2015
Study Type
INTERVENTIONAL
Conditions
Summary
The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of adults for the purposes of obtaining optimal images through MRI.
Eligibility
Min Age: 18 Years
Inclusion Criteria2
- Adults ages 18 years and older
- Participant must be able to hold their breath for up to 16 seconds
Exclusion Criteria7
- History of heart defect
- Pregnancy or positive pregnancy test
- History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month.
- Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week.
- Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula.
- Participant is claustrophobic and unable to tolerate the imaging.
- Standard MRI exclusions (metal, implants).
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Interventions
DRUGHyperpolarized 129 Xenon
During the scans, subject will inhale hyperpolarized Xenon gas for up to 16 seconds per scan, for up to 4 separate MR scans
DEVICEMRI
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT02316379
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