RecruitingNot ApplicableNCT02354274

Novel Approach to Radiotherapy in Locally Advanced Lung Cancer Concomitant Navelbine®

Novel Approach to Radiotherapy in Locally Advanced Lung Cancer - Heterogeneous FDG-guided Dose Escalation With Concomitant Navelbine®


Sponsor

Olfred Hansen

Enrollment

330 participants

Start Date

Jan 1, 2015

Study Type

INTERVENTIONAL

Conditions

Summary

To investigate the effect of escalation of radiation dose to tumor and lymph nodes based on an inhomogeneous dose distribution controlled by FDG-PET positive areas compared to a standard homogeneous dose spread


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying a new radiation treatment approach combined with a chemotherapy drug (vinorelbine/Navelbine) for patients with locally advanced non-small cell lung cancer (NSCLC) that cannot be removed with surgery. **You may be eligible if...** - You have been confirmed by biopsy to have locally advanced non-small cell lung cancer (stage IIB to IIIB) - Your general health score (ECOG) is 0 or 1 (fully active or able to carry out light work) - You are able to follow the treatment and study schedule - Women must have a negative pregnancy test - A standard radiation plan meeting safety requirements is available for you **You may NOT be eligible if...** - You have an unstable medical condition (such as severe infection, heart disease, or serious liver or kidney problems) - You need supplemental oxygen through the nose - You have previously had chest radiation - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONEscalated: Inhomogeneous dose plan
RADIATIONStandard: Homogeneous dose plan

Locations(7)

Aalborg University Hospital

Aalborg, Denmark

Aarhus University Hospital

Aarhus, Denmark

Rigshospitalet

Copenhagen, Denmark

Herlev University Hospital

Herlev, Denmark

Department of Oncology, Naestved Hospital

Næstved, Denmark

Department of Oncology, Odense University Hospital

Odense, Denmark

Department of Oncology, Vejle Hospital

Vejle, Denmark

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NCT02354274


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