RecruitingNot ApplicableNCT02354274

Novel Approach to Radiotherapy in Locally Advanced Lung Cancer Concomitant Navelbine®

Novel Approach to Radiotherapy in Locally Advanced Lung Cancer - Heterogeneous FDG-guided Dose Escalation With Concomitant Navelbine®

Sponsor

Olfred Hansen

Enrollment

330 participants

Start Date

Jan 1, 2015

Study Type

INTERVENTIONAL

Conditions

NSCLC

Summary

To investigate the effect of escalation of radiation dose to tumor and lymph nodes based on an inhomogeneous dose distribution controlled by FDG-PET positive areas compared to a standard homogeneous dose spread

Eligibility

Min Age: 18 Years

Inclusion Criteria6

Patients with histologically or cytologically proven locally advanced NSCLC stage IIB to IIIB
Performance status 0-1
Able to comply with treatment and follow study and follow-up procedures
Women must have negative pregnancy test
Signed, informed consent
Plan for radiotherapy with conventional 66 Gy/ 33 F, which meets all dosing limits two normal tissue must be available

Exclusion Criteria7

Any unstable systemic disorder (including infection , unstable angina, congestive heart failure , severe liver , kidney or metabolic disease)
Need for nasal oxygen
Former thoracic radiotherapy, unless there is no significant overlap with previous fields
Any other active malignant disease
Unable to take oral medications or needing intravenous nutrition
Ulcer
Nursing women