RecruitingNot ApplicableNCT02464696

Non-invasive Ventilation in Reducing the Need for Intubation in Patients With Cancer and Respiratory Failure

A Prospective Randomized Controlled Trial of Early Non-Invasive Positive Pressure Ventilation in Patients With Hypoxemic Respiratory Failure and Malignancies


Sponsor

M.D. Anderson Cancer Center

Enrollment

256 participants

Start Date

Oct 6, 2015

Study Type

INTERVENTIONAL

Conditions

Summary

This randomized clinical trial studies how well non-invasive ventilation works in reducing the need for intubation, or placement of a tube in the windpipe, in patients with cancer and respiratory failure. Respiratory failure is a condition in which not enough oxygen passes from the lungs to the blood, and is a common cause of admission to the emergency room in patients with hematological and solid tumor patients. Non-invasive positive pressure ventilation (NIPPV) is a method of delivering oxygen using a mask. It is not yet known whether NIPPV is better at improving the amount of oxygen in the blood, reducing shortness of breath, and the need for intubation than standard high flow oxygen (a tube with 2 prongs placed in the nostrils) in patients with cancer and respiratory failure.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Methylprednisolone, a procedure called Oxygen Therapy, and others for people with hematopoietic and lymphoid cell neoplasm and malignant solid neoplasm. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMethylprednisolone

IPS cohort only

PROCEDUREOxygen Therapy

Receive high flow oxygen therapy

DEVICEPositive Air Pressure Device

Undergo NIPPV


Locations(1)

M D Anderson Cancer Center

Houston, Texas, United States

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NCT02464696


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