Fecal Microbiota Transplantation as a Strategy to Eradicate Resistant Organisms

This pilot study evaluates whether fecal microbiota transplantation (FMT) — transferring stool from a healthy donor into a patient's gut via a nasogastric tube — can eliminate intestinal colonization with extended-spectrum resistant (ESC-R) Enterobacteriaceae, a group of antibiotic-resistant bacteria that can cause serious infections, in children and adolescents. Children and adolescents aged 7–21 with a history of at least one infection caused by these resistant bacteria and confirmed ongoing gut colonization are eligible; patients who are immunocompromised, on immunosuppressants, pregnant, or have significant gastrointestinal conditions are excluded. The FMT is performed as an outpatient procedure, and participants provide stool samples at 2 days, 2 weeks, 1 month, 2 months, 6 months, and 12 months afterward to check whether the resistant bacteria have been cleared. This summary was prepared as patient-facing educational content using AI assistance.