RecruitingNCT02579278

Circulating Tumour DNA (ctDNA) in Patients With Colorectal Cancer and the Relationship to Imaging Features of Extramural Venous Invasion

Sponsor

Imperial College London

Enrollment

100 participants

Start Date

Nov 1, 2015

Study Type

OBSERVATIONAL

Conditions

Cancer Rectal Cancer

Summary

This study does not involve randomization or treatment. Eligible patients have colorectal adenocarcinoma with no metastases eligible for curative surgery. A pre operative staging scan must have been completed within 6 weeks prior to surgery. Two x 20ml blood samples will be taken from each patient, one prior to and one during or within 24hrs after surgery. Patients are annually followed up to 3 years.

Eligibility

Min Age: 16 Years

Inclusion Criteria6

Have a biopsy-confirmed colorectal adenocarcinoma
Is eligible for curative surgery
Has no metastatic disease on CT scan
Has completed pre-operative staging scan within six weeks prior to surgery
Have provided written informed consent to participate in the study
Be aged 16 years or over

Exclusion Criteria3

Have metastatic disease (including resectable liver metastases)
Have a synchronous second malignancy
Are contraindicated for any imaging able to determine EMVI status

Interventions

OTHERBlood sample (mrEMVI positive patient)

Two blood samples are taken from each patient with mrEMVI positive tumours post chemoradiotherapy. One pre-surgery and one during surgery from a peripheral vein.

OTHERBlood sample (mrEMVI negative patient)