Whole Transcriptome Profiling and Metabolic Phenotyping in Children With ROHHAD Syndrome
Columbia University
12 participants
Nov 1, 2015
OBSERVATIONAL
Conditions
Summary
Rapid onset Obesity, Hypoventilation, Hypothalamic dysfunction and Autonomic Dysregulation (ROHHAD) is a syndrome named in 2007. The hallmark of the syndrome is the rapid onset obesity and dysregulation of central ventilation. There is little information about the metabolic changes that lead to the rapid onset obesity in these children. The investigators would like to study the metabolic phenotype of these children to understand the disturbances in energy balance that lead to the rapid onset obesity.
Eligibility
Inclusion Criteria1
- Children with ROHHAD syndrome
Exclusion Criteria1
- Children with known genetic causes of obesity
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Interventions
The investigators will obtain blood to extract peripheral mononuclear cells. These cells will be used to generate patient specific hypothalamic cells that will be used for transcriptome profiling.
Locations(2)
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NCT02602769