RecruitingNCT02611089
Muscle Connective Tissue in Limb Development and Disease
Sponsor
King's College London
Enrollment
150 participants
Start Date
Feb 20, 2016
Study Type
OBSERVATIONAL
Conditions
Summary
The objective of this work is to understand how the disruption of the muscle connective tissue contributes to the limb soft-tissue defects in radial dysplasia. In parallel, the researchers will investigate the role of muscle connective tissue in normal limb development.
Eligibility
Inclusion Criteria7
- Cases
- Patients with a clinical diagnosis of radial dysplasia, requiring reconstructive surgery
- Either sex
- Informed (parental) consent to participate
- Patients with an injury requiring reconstructive surgery
- Either sex
- Informed (parental) consent to participate
Exclusion Criteria7
- Patients with a clinical diagnosis of radial dysplasia, but not requiring reconstructive surgery
- Patients with a diagnosis other than radial dysplasia
- Patients with extensive previous scarring to their forearm and hand.
- Patients with a significant pathological skin or soft tissue lesion at the donor site.
- Controls
- Patients with extensive previous scarring to their forearm and hand.
- Patients with a significant pathological skin or soft tissue lesion at the donor site.
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Interventions
PROCEDURETissue biopsy
Sampling of tissue as described.
Locations(5)
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NCT02611089