RecruitingPhase 1NCT02637934

Phase I Pilot Study of Biodistribution, Metabolism and Excretion of Novel Radiotracer [18F]Fluorthanatrace (FTT) by PET/CT


Sponsor

Abramson Cancer Center at Penn Medicine

Enrollment

35 participants

Start Date

Jan 14, 2016

Study Type

INTERVENTIONAL

Conditions

Summary

Up to 40 evaluable women with known or suspected epithelial ovarian, fallopian tube, or primary peritoneal cancer will participate in two different imaging cohorts. The Biodistribution cohort will include up to 4 patients and the Dynamic cohort will include up to 36 patients. Human dosimetry will be calculated from the Biodistribution cohort. The Dynamic cohort date will evaluate preliminary information on uptake of \[18F\]FTT in gynecological cancer and compare with PARP-1 activity in tissue.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new drug to understand how the body processes it (absorption, breakdown, and elimination), with a focus on how it behaves in patients with a specific type of cancer, helping researchers determine the right dose and schedule for future treatments. **You may be eligible if...** - You have a cancer diagnosis that meets the study criteria - Your liver and kidneys are functioning well enough to process the study drug - You are in adequate overall health (measured by a performance score) - You have not received certain treatments that could interfere with the study **You may NOT be eligible if...** - You have serious liver or kidney problems - You are taking medications that could interact with the study drug - You are pregnant or breastfeeding - You have had recent major surgery - You have a serious infection or uncontrolled medical condition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUG[18F]FluorThanatrace
RADIATIONPET/CT imaging sessions

Locations(1)

Abramson Cancer Center of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

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NCT02637934