Study of the Involvement of IL-17 / IL-22 Pathway in Bacterial Exacerbations of COPD
University Hospital, Lille
100 participants
Jul 4, 2018
INTERVENTIONAL
Conditions
Summary
Chronic obstructive pulmonary disease (COPD) is a worldwide chronic inflammatory disease of the airways linked to environmental exposure. The chronic course of COPD is often interrupted by acute exacerbations which have a major impact on the morbidity and mortality of COPD patients. A bacterial etiology for these exacerbations is common (almost 50%). Moreover, airway bacterial colonization linked to an increased susceptibility is observed in COPD patients. Effective Th17 immune response is needed to develop a good response against bacteria. Thus, this study aims to demonstrate that there is a defective IL-17/ IL-22 response to bacteria in COPD leading to airway bacterial colonization and infection.
Eligibility
Inclusion Criteria3
- Diagnosed COPD according GOLD guidelines
- Current or ex-smoker (at least 10 pack-years)
- Hospitalized for COPD exacerbation
Exclusion Criteria8
- Asthma or Cystic fibrosis
- No other chronic lung disease
- Solid Tumor unhealed or not considered in remission
- Inhaled drug consumption
- Women of childbearing potential without effective contraception
- Pregnant or breastfeeding women
- Incapable of consent
- Lack of social security coverage
Interventions
Collect sputum, blood and nasopharyngeal swab during the exacerbation and at steady state 8 to 16 weeks later.
Measure lung function and follow it during 4 years
Locations(4)
View Full Details on ClinicalTrials.gov
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NCT02655302