Observational Prospective Research Study In Monoclonal Gammopathies leadINg to Myeloma

This study is tracking people who have an early or precursor form of multiple myeloma (a type of blood cancer involving abnormal protein-producing cells) over time to understand who is at risk of progressing to full-blown multiple myeloma and why. **You may be eligible if...** - You have been diagnosed with MGUS (monoclonal gammopathy of undetermined significance) — an early condition where abnormal proteins appear in the blood but have not yet caused organ damage - You have been diagnosed with smoldering multiple myeloma — a more advanced precursor with higher levels of abnormal protein but still no symptoms or organ damage **You may NOT be eligible if...** - You already have active multiple myeloma causing organ damage such as high calcium, kidney failure, anemia, or bone lesions - You have amyloidosis (a condition where abnormal proteins build up in organs) - More than 60% of your bone marrow consists of abnormal plasma cells Talk to your doctor to see if this trial is right for you.