Impact of Fat-free Mass in the Carboplatin Calculated Dose and Chemotherapeutic Toxicity in Patients With Advanced NSCLC

This study is exploring whether a patient's muscle mass affects how their body processes a chemotherapy drug called carboplatin, and whether this influences the drug's effectiveness or side effects in people with advanced lung cancer. **You may be eligible if...** - You have been diagnosed with advanced non-small cell lung cancer (stage IV) - You are starting first-line chemotherapy with carboplatin and paclitaxel - Your kidneys, liver, and blood counts are functioning adequately - You are able to carry out daily activities with minimal assistance (ECOG performance status 0-2) **You may NOT be eligible if...** - You have significant kidney problems - You do not have a CT scan from the start of your treatment - You have uncontrolled high blood pressure (above 140 mmHg) or uncontrolled diabetes - You have a blockage in your kidneys or ureters - You are dehydrated - You regularly take high doses of anti-inflammatory medications like aspirin or ibuprofen Talk to your doctor to see if this trial is right for you.