RecruitingNCT02763683

Investigations of Dementia in Parkinson Disease


Sponsor

Washington University School of Medicine

Enrollment

320 participants

Start Date

Jun 1, 2016

Study Type

OBSERVATIONAL

Conditions

Summary

The purpose of this study is to use a brain imaging method called Pittsburgh B (PIB) Positron Emission Tomography (PET) and Vesicular Cholinergic Transport (VAT) PET to determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia.


Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is using advanced brain MRI scans to investigate why some people with Parkinson's disease develop dementia (memory loss and thinking problems) while others do not, in order to find early warning signs. **You may be eligible if...** - You have been diagnosed with Parkinson's disease, showing at least three of the classic signs: resting tremor (shaking at rest), muscle stiffness, slowness of movement, or balance problems — or at least two of these with one side more affected **You may NOT be eligible if...** - You have a history of significant head trauma - You have other major neurological or psychiatric conditions such as stroke, multiple sclerosis, depression, or schizophrenia - You have severe medical illnesses - You cannot lie still for 90 minutes (required for the MRI) - You have metal implants, a pacemaker, or other conditions that make MRI unsafe - You refuse to consent to donating your brain for research after death Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONPiB and VAT

There is no intervention for this study. The PiB and VAT are used during the PET procedures to help to identify any excessive abnormal proteins in the brain.


Locations(1)

Washington University in St. Louis

St Louis, Missouri, United States

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NCT02763683