RecruitingNCT02775461

Pancreas Registry and High Risk Registry

Pancreas Disease and High Risk Registry


Sponsor

Icahn School of Medicine at Mount Sinai

Enrollment

1,368 participants

Start Date

Mar 1, 2013

Study Type

OBSERVATIONAL

Conditions

Summary

The purpose of this study is to establish a registry of patients with pancreatic diseases. Patients included in the registry may include those with: pancreatic cancer, precancerous lesions of the pancreas, inflammatory lesions of the pancreas, cystic lesions of the pancreas, and patients at high-risk of pancreatic cancer such as those with a family history of pancreatic cancer or with a family history of a syndrome known to be associated with pancreatic cancer. Pancreatic cancer is the fourth leading cause of death from cancer in the United States. However, little is known about the development of pancreatic cancer and pancreatic diseases in individuals with the above conditions. Knowledge of how family history, environmental exposures, and inflammatory lesion of the pancreas contribute to the development of pancreatic cancer and pancreatic diseases is essential. You may qualify to take part in this research study because you have inflammation in the pancreas, a pancreatic cyst, pre-cancerous lesions of the pancreas, pancreatic cancer, a family history of pancreatic cancer, or a family history of a syndrome known to be associated with pancreatic cancer. We will also be collecting a blood sample from all participants for DNA isolation. Sometimes we are born with genes or DNA that give us an increased or decreased chance of developing an illness later in life. Genetic material will be isolated from your blood for further study. You may also choose to provide additional blood samples for serum and plasma extraction. Serum and plasma are components of the blood which can be used to measure indicators of disease in the blood, called biomarkers,for pancreatic diseases. Clinical data and biological specimens contained in this study may be used for a wide variety of future related studies to the cause, diagnosis, outcome and treatment of pancreatic cancer. Funds for conducting this research are provided by Mount Sinai.


Eligibility

Min Age: 18 Years

Inclusion Criteria7

  • At least 1 first degree relative affected with Pancreatic Cancer
  • Any of (BRCA1, BRCA2, PALB2, ATM) mutations + 1 family member with Pancreatic Cancer
  • mFAMMM (p16,CDKN2A mutations) + 1 family member with Pancreatic cancer
  • Known mutation carrier for STK11 (Peutz Jeghers Syndrome)
  • Lynch syndrome (HNPCC) + 1 family PDAC
  • Known mutation carrier for Hereditary pancreatitis
  • Individuals with a history of pancreatic cyst(s) (IPMN's) that measure ≥ 1 cm

Exclusion Criteria3

  • Patients who do not speak English or Spanish
  • Refusal by patient
  • Individuals under the age of 18 years

Locations(2)

Mount Sinai West

New York, New York, United States

Icahn School of Medicine at Mount Sinai

New York, New York, United States

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NCT02775461


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