Effects of Physical Activity, Ambulatory Blood Pressure and Calcium Score on Cardiovascular Health in Normal People
SingHEART: Effects of Physical Activity, Ambulatory Blood Pressure and Calcium Score on Cardiovascular Health in Normal People
National Heart Centre Singapore
1,000 participants
Oct 1, 2015
OBSERVATIONAL
Conditions
Summary
A prospective cohort of relatively healthy individuals, using comprehensive clinical information, advanced imaging (including cardiac MRI), cardiovascular exercise physiology, metabolomics and genetic analysis. These findings will be correlated with adverse clinical outcomes including death, stroke and myocardial infarction. In selected cases, follow-up imaging and biomarker samples will also be obtained. These studies will enable us to begin to address a critical gap in our knowledge as to how best to interpret the very large amount of cardiovascular tests done in Singapore and how to better to predict outcomes and manage healthcare costs in our local populations
Eligibility
Inclusion Criteria1
- Men and women age 21-69 years
Exclusion Criteria16
- Previous myocardial infarction (MI). This will include ST-elevation MI (STEMI) and non-ST-elevation MI (NSTEMI)
- Known coronary artery disease - prior coronary revascularization
- Known documented peripheral arterial disease
- Previous stroke
- a. Stroke is defined as new focal neurological deficit persisting more than 24hours21.
- More than ongoing use of 2 or more anti-hypertensive agents
- Prior history of cancer (excludes pre-cancerous lesions)
- Expected life expectancy less than 1 year
- Known definite diabetes mellitus or on treatment for diabetes mellitus
- Known autoimmune disease or genetic disease
- Known endocrine disease on treatment
- Psychiatric illness
- Asthma or chronic lung disease requiring long term medications or oxygen
- Chronic infective disease, including tuberculosis, hepatitis B and C; and HIV
- Inability to comply with study protocol
- Any other acute or chronic medical or physical condition deemed by the investigator to affect study outcomes
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT02791152