Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT

This study is testing whether following a reduced-calorie diet during radiation therapy can improve treatment outcomes and reduce side effects for people with soft tissue sarcoma (cancer of muscle, fat, or connective tissue) in the leg. **You may be eligible if...** - You are over 18 years old - You have a biopsy-confirmed soft tissue sarcoma in the lower limb - You are scheduled to receive radiation therapy before surgery, or for a recurring tumor, followed by surgical removal - Your general fitness is adequate (Karnofsky score of 60% or higher) - Your BMI is 20 or above - Your blood protein levels, kidney and liver function, and blood counts are all within normal range **You may NOT be eligible if...** - You are currently pregnant or breastfeeding - You have been diagnosed with another cancer within the past 5 years - You have diabetes - You currently take metformin - You have other health conditions that would interfere with a calorie-restricted diet Talk to your doctor to see if this trial is right for you.