RecruitingEarly Phase 1NCT02823665
The Effects of Bariatric Surgeries on Glucose Metabolism
Sponsor
The University of Texas Health Science Center at San Antonio
Enrollment
200 participants
Start Date
Jul 1, 2015
Study Type
INTERVENTIONAL
Summary
The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.
Eligibility
Min Age: 18 YearsMax Age: 65 Years
Inclusion Criteria4
- Hypoglycemic RYGB patients with documented blood glucose level <50 mg/dl
- Asymptomatic individuals with bariatric surgery
- Healthy non-surgical patients with no personal history of diabetes
- Subjects must physically be able to come to our clinical research center Cedars-Sinai Medical Center
Exclusion Criteria10
- Active heart, lung, liver, gastrointestinal or kidney disease; unable to give informed consent; pregnancy; uncontrolled high blood pressure or high cholesterol; significant anemia (hemoglobin <11g/dL); prisoners or institutionalized individuals; type 2 diabetes mellitis; development of any serious medical or psychiatric illness during recruitment or studies;
- RYGB patients will be disqualified if they have gastric outlet obstruction or severe diarrhea.
- Healthy non-surgical patients with personal history of diabetes
- For administration of atropine, the following exclusions also apply:
- History of glaucoma
- Uncontrolled hypertension (any subjects with BP>140/90 and history of dyslipidemia
- Taking any medication that might interact with atropine and cannot be stopped will be excluded from the study)
- Myasthenia gravis
- Brain pathology
- Enlarged prostate in men
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Interventions
DRUGExendin-(9-39)
A physiological study to evaluate the role of GLP-1 on glucose metabolism and insulin secretin after glucose and protein ingestion.
DRUGAtropine
A physiological study to evaluate the effect of neural activation on insulin secretion and glucose metabolism.
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT02823665