RecruitingEarly Phase 1NCT02823665

The Effects of Bariatric Surgeries on Glucose Metabolism

Sponsor

The University of Texas Health Science Center at San Antonio

Enrollment

200 participants

Start Date

Jul 1, 2015

Study Type

INTERVENTIONAL

Conditions

Sleeve Gastrectomy Post-bariatric Surgery Gastric Bypass Hypoglycemia After Gastric Bypass

Summary

The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria4

Hypoglycemic RYGB patients with documented blood glucose level <50 mg/dl
Asymptomatic individuals with bariatric surgery
Healthy non-surgical patients with no personal history of diabetes
Subjects must physically be able to come to our clinical research center Cedars-Sinai Medical Center

Exclusion Criteria10

Active heart, lung, liver, gastrointestinal or kidney disease; unable to give informed consent; pregnancy; uncontrolled high blood pressure or high cholesterol; significant anemia (hemoglobin <11g/dL); prisoners or institutionalized individuals; type 2 diabetes mellitis; development of any serious medical or psychiatric illness during recruitment or studies;
RYGB patients will be disqualified if they have gastric outlet obstruction or severe diarrhea.
Healthy non-surgical patients with personal history of diabetes
For administration of atropine, the following exclusions also apply:
History of glaucoma
Uncontrolled hypertension (any subjects with BP>140/90 and history of dyslipidemia
Taking any medication that might interact with atropine and cannot be stopped will be excluded from the study)
Myasthenia gravis
Brain pathology
Enlarged prostate in men