Therapeutic Effects of R-IDARAM and Intrathecal Immunochemotherapy on Elderly Patients With PCNSL

This study is testing a combination of chemotherapy drugs given both intravenously and directly into the fluid surrounding the brain and spinal cord, for elderly patients with a rare brain cancer called primary central nervous system lymphoma (PCNSL) — a type of lymphoma that starts in the brain. **You may be eligible if...** - You have been newly diagnosed with non-Hodgkin's lymphoma confirmed by a biopsy - The lymphoma is located only in the brain, the membranes around the brain or spinal cord, the spinal fluid, or the eyes - You are between 18 and 75 years old - You have adequate blood counts and have never had another cancer **You may NOT be eligible if...** - The lymphoma has spread outside the brain, spinal cord, spinal fluid, or eyes - You are under 18 or over 75 years old - Your blood counts are too low - You are HIV positive - You have significant kidney, heart, lung, or liver problems - You have an uncontrolled active infection - You have previously been treated for this brain lymphoma (except with steroids) Talk to your doctor to see if this trial is right for you.