Cohort Biomonitoring Study to Evaluate the Biocompatibilty of Resin-based Dental Materials
Universitaire Ziekenhuizen KU Leuven
100 participants
May 2, 2018
INTERVENTIONAL
Conditions
Summary
Adult patients who require multiple dental restorations will be included in this study. Urine and saliva samples will be taken for determination of bisphenol A levels at several time points, and for analysis of the estrogenic activity using ERE-CALUX. Also buccal cells will be taken. Next, DNA extraction will be done with a commercial kit. We will determine global alterations in DNA methylation and DNA hydroxymethylation levels using UPLC-MS/MS.
Eligibility
Inclusion Criteria1
- Caucasian, adults,
Exclusion Criteria1
- acute or chronic medical condition, presence of oral inflammatory conditions during the previous 2 weeks, chronic disease requiring intake of drugs, exposure to diagnostic X-rays in the previous 2 months, smoking and consumption of alcohol
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Interventions
Damaged teeth will be restored
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT02874599