Palbociclib and Pembrolizumab In Central Nervous System Metastases

This study tests two drugs — palbociclib and pembrolizumab — in patients with cancer that has spread to the brain (brain metastases), to see if this combination can slow or stop tumor growth in the brain. **You may be eligible if...** - You have been diagnosed with any solid tumor (such as breast cancer, lung cancer, etc.) that has spread to the brain - There is at least one measurable brain tumor on a scan - Your brain tumors are growing or getting worse - You are in acceptable overall health **You may NOT be eligible if...** - You have no measurable tumors in the brain - Your brain tumors have not progressed (gotten worse) - You have certain infections, serious heart conditions, or severe immune system problems - You are pregnant or breastfeeding Treating brain metastases is very challenging, and this study may help identify new options for patients whose cancer has spread to the brain. Talk to your doctor to see if this trial is right for you.